Vestigial Like 2 (Drosophila) (VGLL2) (AA 34-79) anticorps

N° du produit ABIN6711035

Détail du produit

Antigène:

Vestigial Like 2 (Drosophila) (VGLL2)

Épitope: AA 34-79

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Specificité: VGLL2 polyclonal antibody detects endogenous levels of VGLL2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95% (by SDS-PAGE)

Immunogène: Synthetic peptide, corresponding to amino acids 34-79 of Human VGLL2.

Information d'application

Indications d'application: WB: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term.

Détail du antigène

Antigène:

Vestigial Like 2 (Drosophila) (VGLL2)

Autre désignation: VGLL2 (VGLL2 Antibody Extrait)

Synonymes: vgll2a, MGC114146, zgc:114146, vgl-2, VGL2, VITO1, C130057C21Rik, VITO-1, Vito1, vestigial like family member 2, vestigial-like family member 2a, vestigial like family member 2 L homeolog, vestigial-like family member 2, VGLL2, vgll2a, vgll2.L, Vgll2

Sujet: Vgl-2 (Transcription cofactor vestigial-like protein 2), also known as VITO-1, is a 317 amino acid protein that contains a domain through which it interacts with TEF-1, a protein that plays a role in controlling the expression of numerous genes. Specific to skeletal muscle, Vgl-2 is expressed highly in adult fast muscle and is expressed at lower levels in adult slow muscle and fetal skeletal muscle. During muscle differentiation, Vgl-2 mRNA levels increase and Vgl-2 translocates from the cytoplasm to the nucleus.Overexpression of Vgl-2 in MYOD-transfected 10T1/2 mouse embryonic fibroblasts increases expression of myosin heavy chain (MHC), which is a marker of terminal muscle differentiation. This evidence suggests that Vgl-2 is essential for muscle gene expression. There are two isoforms of Vgl-2 that are produced as a result of alternative splicing events.

Poids moléculaire: ~ 33 kDa

UniProt: Q8N8G2