Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CDK4 anticorps (AA 241-303)

CDK4 Reactivité: Humain, Souris, Rat, Mouton WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN671166
  • Antigène Voir toutes CDK4 Anticorps
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Épitope
    • 23
    • 16
    • 15
    • 9
    • 9
    • 9
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 241-303
    Reactivité
    • 119
    • 75
    • 54
    • 18
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Mouton
    Hôte
    • 107
    • 34
    • 2
    • 1
    Lapin
    Clonalité
    • 106
    • 37
    Polyclonal
    Conjugué
    • 83
    • 11
    • 11
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CDK4 est non-conjugé
    Application
    • 121
    • 54
    • 36
    • 31
    • 21
    • 19
    • 16
    • 14
    • 13
    • 12
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Rat, Mouton
    Homologie
    Cow,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human CDK4
    Isotype
    IgG
    Top Product
    Discover our top product CDK4 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Zhou, Liu, Cai, Liu, Jiang, Wang: "Protective effects of ginsenoside Rg1 on aging Sca?1+ hematopoietic cells." dans: Molecular medicine reports, Vol. 12, Issue 3, pp. 3621-8, (2015) (PubMed).

    Yang, Wang, Hui, Li, Jiang: "SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/?-catenin pathway." dans: Tumour biology, (2015) (PubMed).

  • Antigène
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Autre désignation
    CDK4 (CDK4 Produits)
    Synonymes
    anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
    Sujet

    Synonyms: CMM3, PSK-J3, Cyclin-dependent kinase 4, Cell division protein kinase 4, CDK4

    Background: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

    ID gène
    1019
    UniProt
    P11802
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
Vous êtes ici:
Support technique