HSP90AA2 anticorps (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 2) (AA 671-720)

Details for Product anti-HSP90AA2 Antibody No. ABIN6711796
Antigène
  • HSP90ALPHA
  • HSPCA
  • HSPCAL3
  • heat shock protein 90 alpha family class A member 2, pseudogene
  • HSP90AA2P
Épitope
AA 671-720
42
15
15
15
3
2
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
184
151
150
5
3
3
3
3
2
Hôte
Lapin
132
51
2
Clonalité
Polyclonal
Conjugué
Cet anticorp HSP90AA2 est non-conjugé
9
7
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
144
119
96
48
28
27
27
19
12
1
1
Options
Immunogène Synthetic peptide, corresponding to amino acids 671-720 of Human HSP90alpha.
Specificité HSP90α (P717) polyclonal antibody detects endogenous levels of HSP90α protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others HSP90AA2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation HSP90alpha (HSP90AA2 Antibody Extrait)
Sujet In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2 % of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90.
Poids moléculaire ~ 85, 90 kDa
UniProt P07900
Indications d'application WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Images (Fournisseur)
Western Blotting (WB) image for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 2 (HSP90AA2) (AA 671-720) antibody (ABIN6711796) Western blot (WB) analysis of HSP90α (P717) polyclonal antibody at 1:500 dilution Lan...
Produit citée dans: Fan, Yan, Zhang, Zhang, Gao, Xu, Wang, Meng: "Increased expression of Gp96 by HBx-induced NF-κB activation feedback enhances hepatitis B virus production." dans: PLoS ONE, Vol. 8, Issue 6, pp. e65588, 2014 (PubMed).

Wu, Xu, You, Guo, Feng, Zhang, Wu: "Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation." dans: International journal of molecular medicine, Vol. 30, Issue 5, pp. 1138-44, 2013 (PubMed).

Fu, Chen, Zhao, Zhao, Zhou, Xu, Xin, Liu, Luo, Yin: "Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3." dans: PLoS ONE, Vol. 7, Issue 11, pp. e49194, 2013 (PubMed).

Wang, Zhao, Qi, Gu, Rong, Mu, Zou, Tao, You, Guo: "Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP." dans: Journal of cellular biochemistry, Vol. 112, Issue 2, pp. 509-19, 2011 (PubMed).

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