STAT1 anticorps (Signal Transducer and Activator of Transcription 1, 91kDa) (AA 680-720)

Details for Product anti-STAT1 Antibody No. ABIN6711904
Antigène
  • CANDF7
  • ISGF-3
  • STAT91
  • 2010005J02Rik
  • AA408197
  • XStat1
  • STAT4
  • DD6G4-4
  • STAT
  • STAT1
  • dZ182H3.3
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
  • stat1
  • signal transducer and activator of transcription 1
  • signal transducer and activator of transcription 1 L homeolog
  • signal transducer and activator of transcription 1, 91kDa
  • signal transducer and activator of transcription 4
  • signal transducer and activator of transcription 1a
  • STAT1
  • Stat1
  • stat1.L
  • stat4
  • stat1a
Épitope
AA 680-720
101
74
52
17
17
15
9
8
8
8
8
7
5
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
563
313
281
33
29
26
22
22
16
13
11
7
7
5
2
2
2
1
1
1
1
1
Hôte
Lapin
484
105
2
2
1
1
Clonalité
Polyclonal
Conjugué
Cet anticorp STAT1 est non-conjugé
18
14
13
11
11
11
11
11
11
6
6
5
5
5
5
5
4
2
2
2
Application
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
447
204
163
112
91
65
48
19
18
9
7
6
5
3
1
1
Options
Immunogène Synthetic peptide, corresponding to amino acids 680-720 of Human Stat1.
Specificité Stat1 (G695) polyclonal antibody detects endogenous levels of Stat1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others STAT1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Stat1 (STAT1 Antibody Extrait)
Sujet Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Poids moléculaire ~ 87 kDa
UniProt P42224
Pathways Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
Indications d'application WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Images (Fournisseur)
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 680-720) antibody (ABIN6711904) Western blot (WB) analysis of Stat1 (G695) polyclonal antibody at 1:1000 dillution La...
Produit citée dans: Shi, Che, Liu et al.: "Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal ..." dans: International journal of molecular sciences, Vol. 14, Issue 12, pp. 24656-69, 2014 (PubMed).

Chen, Wang, Xie, Ma, Wang: "STAT1 negatively regulates hepatocellular carcinoma cell proliferation." dans: Oncology reports, Vol. 29, Issue 6, pp. 2303-10, 2013 (PubMed).

Zhu, Gao, Qi, Hong, Li, Wang, McHepange, Zhang, Wei, Chen: "Local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata." dans: Antiviral research, Vol. 88, Issue 2, pp. 187-92, 2010 (PubMed).

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