SMAD2 anticorps (SMAD, Mothers Against DPP Homolog 2) (AA 426-476)

Details for Product anti-SMAD2 Antibody No. ABIN6711985
Antigène
  • JV18
  • JV18-1
  • MADH2
  • MADR2
  • hMAD-2
  • hSMAD2
  • jv18
  • Xmad2
  • madh2
  • madr2
  • XSmad2
  • hmad-2
  • hsmad2
  • jv18-1
  • smad-2
  • fj43c06
  • wu:fj43c06
  • 7120426M23Rik
  • Madh2
  • Madr2
  • Smad-2
  • mMad2
  • MAD homolog 2
  • Mothers against DPP homolog 2
  • SMAD 2
  • Smad2
  • SMAD family member 2
  • SMAD family member 2-Z
  • SMAD family member 2 S homeolog
  • SMAD2
  • SMAD2Z
  • smad2
  • smad2.S
  • Smad2
Épitope
AA 426-476
65
61
36
33
21
18
15
13
12
11
11
11
8
7
6
6
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
491
291
262
29
20
19
18
18
13
12
10
10
7
7
7
4
1
1
1
1
1
Hôte
Lapin
434
55
18
Clonalité
Polyclonal
Conjugué
Cet anticorp SMAD2 est non-conjugé
26
12
12
10
10
10
10
10
10
7
7
7
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
391
200
109
82
54
27
26
25
22
20
19
5
5
4
3
3
1
Options
Immunogène Synthetic peptide, corresponding to amino acids 426-476 of Human Smad2.
Specificité Smad2 (P459) polyclonal antibody detects endogenous levels of Smad2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others SMAD2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Smad2 (SMAD2 Antibody Extrait)
Sujet Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of GFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.
Poids moléculaire ~ 60 kDa
UniProt Q15796
Pathways Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
Indications d'application WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Images (Fournisseur)
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 426-476) antibody (ABIN6711985) Western blot (WB) analysis of SMAD2 pAb at 1:500 dilution Lane1:HCC827 whole cell lys...
Produit citée dans: Zhu, Wu, Yan, Hu, Yuan, Dong, Li, Jing, Yang, Guo: "Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative response in human hepatocellular carcinoma." dans: Hepatology (Baltimore, Md.), Vol. 58, Issue 6, pp. 2012-22, 2014 (PubMed).

Ma, Chen, Xia, Shu, Guo, Wang, Xu, Bai, Zhang, Zhang, Zhang, Wang, Leng: "Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression." dans: International journal of oncology, Vol. 42, Issue 3, pp. 1093-104, 2013 (PubMed).

Li, Zhang, Li, Cui, Pan, Liu, Xing, Lu: "MAWBP and MAWD inhibit proliferation and invasion in gastric cancer." dans: World journal of gastroenterology, Vol. 19, Issue 18, pp. 2781-92, 2013 (PubMed).

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