alpha Tubulin anticorps (TUBA1) (AA 201-256)

Details for Product anti-TUBA1 Antibody No. ABIN6712205
Antigène
  • Tuba1
  • K-ALPHA-1
  • Tuba-1
  • cb944
  • fb22g06
  • tuba1
  • wu:fb22g06
  • Calpha1
  • tubulin, alpha 1A
  • tubulin alpha 1b
  • tubulin, alpha 1b
  • tubulin, alpha 1B
  • Tuba1a
  • TUBA1B
  • tuba1b
  • Tuba1b
Épitope
AA 201-256
32
28
17
12
11
9
9
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
301
186
175
41
36
35
26
19
18
17
13
10
10
10
8
8
8
8
8
7
7
6
6
6
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Hôte
Lapin
189
132
24
5
2
2
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp alpha Tubulin est non-conjugé
22
10
8
8
8
8
8
8
8
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
270
111
102
90
73
72
55
31
18
16
13
8
3
2
1
1
1
Options
Immunogène Synthetic peptide, corresponding to amino acids 201-256 of Human Tubulin alpha.
Specificité Tubulin α (G436) polyclonal antibody detects endogenous levels of Tubulin α protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others alpha Tubulin products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Tubulin alpha (TUBA1 Antibody Extrait)
Sujet Tubulin is a major cytoskeleton component that has three distinct forms, designated α, β and γ Tubulin. α and β Tubulins form heterodimers, which multimerize to form a microtubule filament. γ Tubulin forms a soluble multiprotein particle with several other proteins. This particle, designated the gammasome, is required for nucleating microtubule filaments at the centrosome. In several organisms, numerous isoforms of the Tubulins exist that are encoded by different genes. The α and β isoforms undergo a variety of post-translational modifications, which may affect microtubule stability and protein interactions. High expression of class II β Tubulin has been seen in elongating axons, indicating a role in neurite outgrowth. Tubulins may also play a role in non-neuronal cell process formation.
Poids moléculaire ~ 55 kDa
Pathways Dynamique des Microtubules
Indications d'application WB: 1:5000~20000 IHC: 1:100~500 IF: 1:100~500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Images (Fournisseur)
Western Blotting (WB) image for anti-alpha Tubulin (TUBA1) (AA 201-256) antibody (ABIN6712205) Western blot (WB) analysis of Tubulin α (G436) pAb at 1:5000/1:10000/1:20000 dilution...
Produit citée dans: Liu, Luo, Xie, Tang, Chen, Wu, Zhong, Zhao: "Glycogen Synthase Kinase 3β Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells." dans: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, Vol. 24, Issue 2, pp. 116-23, 2013 (PubMed).

Zhu, Zhu, Lu, Wang, Wang, Jiang, Shu, Liu: "miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2." dans: Medical oncology (Northwood, London, England), Vol. 29, Issue 1, pp. 384-91, 2012 (PubMed).

Zhu, Xu, Zhu, Zhi, Wang, Wang, Jiang, Shu, Liu: "miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP." dans: Cancer chemotherapy and pharmacology, Vol. 69, Issue 3, pp. 723-31, 2012 (PubMed).

Wang, Wu, Chen, Liu, Liu, Zhang, Yu, Hai: "Does insulin bolster antioxidant defenses via the extracellular signal-regulated kinases-protein kinase B-nuclear factor erythroid 2 p45-related factor 2 pathway?" dans: Antioxidants & redox signaling, Vol. 16, Issue 10, pp. 1061-70, 2012 (PubMed).

Dong, Xu, Miao, Fu, Li, Tang, Wang: "Hypoxia decreased chemosensitivity of breast cancer cell line MCF-7 to paclitaxel through cyclin B1." dans: Biomedicine & pharmacotherapy, Vol. 66, Issue 1, pp. 70-5, 2012 (PubMed).

Lee, Kim, Kim, Hwang, Kim, Lim, Sohn, Yoon, Kim, Park, Park, Ryoo, Lee: "DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1." dans: Biochemical and biophysical research communications, Vol. 420, Issue 1, pp. 91-5, 2012 (PubMed).

Jeong, Moon, Bae, Lee, Seol, Kang, Kim, Kang, Park: "Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity." dans: Neuroscience research, Vol. 73, Issue 2, pp. 99-105, 2012 (PubMed).

Wang, Gu, He, Ye, Chen, Zhang, Hai: "Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress." dans: Biochimie, Vol. 94, Issue 8, pp. 1705-17, 2012 (PubMed).

Cai, Han, Bei, Liu, Lei, Cui, Feng, Wang, Zhang, Liang, Chen, Kang, Shao, Zeng: "Expression of human leukocyte antigen G is associated with prognosis in nasopharyngeal carcinoma." dans: International journal of biological sciences, Vol. 8, Issue 6, pp. 891-900, 2012 (PubMed).

Zhu, Shan, Wang, Shu, Liu: "miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines." dans: International journal of cancer, Vol. 127, Issue 11, pp. 2520-9, 2010 (PubMed).

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