Creatine Kinase, Muscle (CKM) (N-Term) anticorps

Détails pour le produit réf. ABIN6712349
Antigène
  • CKMM
  • M-CK
  • Ckmm
  • MCK
  • ckmm
  • m-ck
  • CKM
  • CK-M
  • cb51
  • ckm
  • mck
  • wu:fa28d05
  • ckm3
  • wu:fb55e09
  • zgc:64204
  • zgc:92070
  • creatine kinase, M-type
  • creatine kinase, muscle
  • creatine kinase, M-type L homeolog
  • creatine kinase, muscle a
  • creatine kinase, muscle b
  • CKM
  • Ckm
  • ckm.L
  • ckm
  • ckma
  • ckmb
Épitope
N-Term
32
21
15
11
9
9
8
4
4
4
2
2
2
2
2
2
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
353
102
70
18
16
8
7
7
6
5
4
2
2
1
1
1
1
Hôte
Lapin
195
109
81
2
1
1
Clonalité
Polyclonal
Conjugué
Inconjugué
36
23
18
15
14
13
4
4
4
4
4
4
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
238
216
90
30
27
27
25
19
13
12
12
7
4
4
2
1
1
1
1
1
Options
Immunogène Synthetic peptide, corresponding to the N-terminus of Human Creatine Kinase M.
Specificité Creatine Kinase M (Y14) polyclonal antibody detects endogenous levels of Creatine Kinase M protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Antigène
Autre désignation Creatine Kinase M (CKM Antibody Extrait)
Sujet Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. The CKM isoform, predominant in skeletal muscle and heart tissue, is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. CKM reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.
Poids moléculaire ~ 43 kDa
UniProt P06732
Indications d'application WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Produit citée dans: Chen, Li, Zhao, Li, Meng, Mu, Yan, Zhou: "Metallothioneins protect cytosolic creatine kinases against stress induced by nitrogen-based oxidants." dans: The Biochemical journal, Vol. 441, Issue 2, pp. 623-32, 2012 (PubMed).

Chen, Zhao, Li, Gao, Meng, Yan, Zhou: "Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin." dans: The Biochemical journal, Vol. 436, Issue 2, pp. 437-45, 2011 (PubMed).

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