PDGFRB anticorps (Platelet-Derived Growth Factor Receptor, beta Polypeptide) (AA 711-760)

Details for Product anti-PDGFRB Antibody No. ABIN6713336
Antigène
  • AI528809
  • CD140b
  • PDGFR-1
  • Pdgfr
  • CD140B
  • IBGC4
  • JTK12
  • PDGFR
  • PDGFR1
  • platelet derived growth factor receptor, beta polypeptide
  • platelet derived growth factor receptor beta
  • Pdgfrb
  • PDGFRB
Épitope
AA 711-760
37
36
35
33
27
23
18
15
14
13
12
11
9
6
5
5
5
5
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
498
287
248
9
8
8
8
6
2
2
2
1
1
1
Hôte
Lapin
430
93
5
3
1
Clonalité
Polyclonal
Conjugué
Cet anticorp PDGFRB est non-conjugé
21
15
15
15
15
15
15
14
13
13
11
6
6
6
6
6
4
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC)
298
145
127
85
79
55
53
18
14
12
7
3
2
2
1
Options
Immunogène Synthetic peptide, corresponding to amino acids 711-760 of Human PDGFR-beta.
Specificité PDGFR-β (K745) polyclonal antibody detects endogenous levels of PDGFR-β protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others PDGFRB products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation PDGFR-beta (PDGFRB Antibody Extrait)
Sujet Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.
Poids moléculaire ~ 124, 190 kDa
UniProt P09619
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
Indications d'application IHC: 1:50~1:200 IF: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Produit citée dans: Wang, Liu, Zhao, Jiang, Luo, Wang, Yin: "Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways." dans: Molecular and cellular endocrinology, Vol. 382, Issue 2, pp. 979-88, 2014 (PubMed).

Xie, Wang, Zhang, Yang, Yin, Huang, Chen: "Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-β signalling pathway." dans: Pharmacological reports : PR, Vol. 65, Issue 3, pp. 682-8, 2014 (PubMed).

Xing, Du, Hu, Xu, Zhang, Li, Nie: "Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling." dans: Journal of biomedicine & biotechnology, Vol. 2012, pp. 534384, 2013 (PubMed).

Xing, Hu, Shi, Du: "Implication of PDGF signaling in cigarette smoke-induced pulmonary arterial hypertension in rat." dans: Inhalation toxicology, Vol. 24, Issue 8, pp. 468-75, 2012 (PubMed).

Alexander, Casar, Motohashi, Myers, Eisenberg, Gonzalez, Estrella, Kang, Kawahara, Kunkel: "Regulation of DMD pathology by an ankyrin-encoded miRNA." dans: Skeletal muscle, Vol. 1, pp. 27, 2011 (PubMed).

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