CREB1 anticorps (cAMP Responsive Element Binding Protein 1) (pSer133)

Details for Product anti-CREB1 Antibody No. ABIN6713989
Antigène
  • creb
  • CREB1
  • Creb1
  • CREB
  • 2310001E10Rik
  • 3526402H21Rik
  • AV083133
  • Creb
  • Creb-1
  • creb1
  • zgc:55598
  • cAMP responsive element binding protein 1
  • cAMP responsive element binding protein
  • cAMP responsive element binding protein 1 S homeolog
  • cAMP responsive element binding protein 1a
  • CREB1
  • creb1
  • CREB
  • Creb1
  • creb1.S
  • creb1a
Épitope
pSer133
130
48
47
29
19
19
16
15
12
10
10
9
8
8
8
7
6
5
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
621
388
349
42
37
35
33
26
23
22
16
14
13
6
6
6
1
1
1
1
1
Hôte
Lapin
552
72
12
1
Clonalité
Polyclonal
Conjugué
Cet anticorp CREB1 est non-conjugé
26
15
15
14
13
13
13
13
13
8
7
6
3
3
3
3
3
1
Application
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
452
269
224
96
84
56
42
40
27
18
11
10
5
3
2
2
1
1
Options
Immunogène Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 133.
Specificité P-CREB (S133) polyclonal antibody detects endogenous levels of CREB protein when phosphorylated at Ser133.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others CREB1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation CREB (CREB1 Antibody Extrait)
Sujet Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133.
Poids moléculaire ~ 38 kDa
UniProt P16220
Pathways Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
Indications d'application WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Produit citée dans: Xie, Wang, Lu, Pan, Chen, Liao: "UCH-L1 inhibition involved in CREB dephosphorylation in hippocampal slices." dans: Journal of molecular neuroscience : MN, Vol. 53, Issue 1, pp. 59-68, 2014 (PubMed).

Kong, Ren, Jia, Wang, Zhang, Zhang, Chen, Cao: "Effects of nicorandil in neuroprotective activation of PI3K/AKT pathways in a cellular model of Alzheimer's disease." dans: European neurology, Vol. 70, Issue 3-4, pp. 233-41, 2013 (PubMed).

Wei, Wang, Song, Lu, Zhao, Xia, Chou, Wang, Dai: "Norisoboldine inhibits the production of interleukin-6 in fibroblast-like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF-κB-p65/CREB pathways." dans: Journal of cellular biochemistry, Vol. 113, Issue 8, pp. 2785-95, 2012 (PubMed).

Meng, Jiao, Yu: "Picroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways." dans: International journal of molecular medicine, Vol. 30, Issue 2, pp. 263-70, 2012 (PubMed).

Lu, Liu, Cao, Xue, Liu, Zhao, Shen, Jiang, Xu, Huang, Li: "SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration." dans: Journal of medicinal chemistry, Vol. 54, Issue 10, pp. 3564-74, 2011 (PubMed).

Li, Liu: "The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice." dans: Acta pharmacologica Sinica, Vol. 31, Issue 3, pp. 265-72, 2010 (PubMed).

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