FOXO3 anticorps (Forkhead Box O3) (pSer253)

Details for Product anti-FOXO3 Antibody No. ABIN6714395
Antigène
  • AF6q21
  • FKHRL1
  • FKHRL1P2
  • FOXO2
  • FOXO3A
  • zgc:92176
  • wu:fb50g02
  • wu:fi33f07
  • Fkhrl1
  • Foxo3a
  • FoxO3A
  • 1110048B16Rik
  • 2010203A17Rik
  • C76856
  • Fkhr2
  • FOXO-3
  • FOXO3
  • foxo3a
  • xfoxo3
  • foxO3
  • foxO
  • forkhead box O3
  • forkhead box O3A
  • forkhead box O3 L homeolog
  • FOXO3
  • foxo3a
  • Foxo3
  • foxo3.L
  • foxo3
  • foxO3
Épitope
pSer253
70
46
30
24
17
10
10
9
9
9
9
8
8
8
8
7
7
7
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
399
236
204
20
15
11
9
9
8
7
6
5
4
4
3
1
1
1
Hôte
Lapin
327
54
22
1
Clonalité
Polyclonal
Conjugué
Cet anticorp FOXO3 est non-conjugé
21
15
15
15
15
15
15
8
7
5
5
5
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
268
166
153
80
77
27
19
15
9
9
5
2
1
1
1
Options
Immunogène Synthetic phosphopeptide derived from human FOXO3A around the phosphorylation site of Serine 253.
Specificité P-FoxO3A (S253) polyclonal antibody detects endogenous levels of FoxO3A protein when phosphorylated at Ser253.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others FOXO3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation FoxO3A (FOXO3 Antibody Extrait)
Sujet FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation.FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors.
Poids moléculaire ~ 97 kDa
UniProt O43524
Pathways Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
Indications d'application WB: 1:500~1:1000 IHC: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Images (Fournisseur)
Western Blotting (WB) image for anti-Forkhead Box O3 (FOXO3) (pSer253) antibody (ABIN6714395) Western blot (WB) analysis of p-FoxO3A (S253) pAb at 1:500 dilution Lane1:The Testis ...
Produit citée dans: Liao, Li, Wang, Wang, He, Ye, Qi, Cui, Wu, Jiao, Zhang, Xie, Wang, Ding: "microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 17, pp. 4662-72, 2014 (PubMed).

Xiao, Moon, Yan, Nian, Zhang, Liu, Lu, Guan, Chen, Jiang, Jiang, Liu, Li: "Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction." dans: Basic research in cardiology, Vol. 107, Issue 1, pp. 239, 2012 (PubMed).