TRAF6 anticorps (TNF Receptor-Associated Factor 6)

Details for Product anti-TRAF6 Antibody No. ABIN6714483
Antigène
Reactivité
Humain, Souris, Rat (Rattus)
123
73
68
8
7
6
4
3
3
1
1
Hôte
Lapin
122
8
2
Clonalité
Polyclonal
Conjugué
Cet anticorp TRAF6 est non-conjugé
6
4
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
108
45
36
18
17
14
13
12
3
3
2
2
2
2
1
Options
Immunogène Recombinant full length Human TRAF6.
Specificité TRAF6 polyclonal antibody detects endogenous levels of TRAF6 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pureté > 95% (by SDS-PAGE)
Antigène
Autre désignation TRAF6 (TRAF6 Antibody Extrait)
Sujet Tumor necrosis factor receptor-associated factor 6 (TRAF6) regulates adaptive immunity, innate immunity and bone metabolism. TRAF6 is a ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IκB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub. TRAF6 is essential for activating NFκB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination and activating NFκB signaling pathway.
Poids moléculaire ~ 58 kDa
UniProt Q9Y4K3
Pathways Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades
Indications d'application WB: 1:500~1:2000 IF: 1:50~1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL in PBS with 0.1 %  Sodium Azide, 50 % Glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze-thaw cycles.
Stock 4 °C,-20 °C
Stockage commentaire Store at 4°C short term. Aliquot and store at -20°C long term.
Images (Fournisseur)
Image no. 1 for anti-TNF Receptor-Associated Factor 6 (TRAF6) antibody (ABIN6714483) WesternBlot (WB) analysis of TRAF6 polyclonal antibody in extracts from K562, 293T, C...
Produit citée dans: Zhang, Fu, Zhang, Chen, Zhang, Zhao, Bai, Zhu, Cui, Wang: "Neuroprotective effect of bicyclol in rat ischemic stroke: down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression." dans: Brain research, Vol. 1528, pp. 80-8, 2014 (PubMed).

Wei, Jiao, Wang, Lu, Xia, Wang, Guo, Chou, Dai: "Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE(2), and MMP-13 expression." dans: Acta pharmacologica Sinica, Vol. 34, Issue 3, pp. 403-13, 2013 (PubMed).

Zeng, Zhao, Ma, Jiang, Tu: "Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia." dans: International immunopharmacology, Vol. 14, Issue 4, pp. 558-69, 2012 (PubMed).