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HMGB1 anticorps (AA 75-170)

HMGB1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN671616
  • Antigène Voir toutes HMGB1 Anticorps
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Épitope
    • 21
    • 16
    • 15
    • 11
    • 10
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 75-170
    Reactivité
    • 159
    • 90
    • 89
    • 14
    • 12
    • 12
    • 10
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 136
    • 33
    • 2
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 126
    • 49
    Polyclonal
    Conjugué
    • 90
    • 17
    • 17
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp HMGB1 est non-conjugé
    Application
    • 145
    • 63
    • 47
    • 47
    • 32
    • 31
    • 26
    • 25
    • 21
    • 10
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HMGB1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Li, Xu, Xu, Cai, Sun, Yang, Sun, Lu: "Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression." dans: Molecular and cellular biochemistry, Vol. 420, Issue 1-2, pp. 161-70, (2016) (PubMed).

    Li, Jia, Ji, Gong, Wang, Zhang, Wang, Zang: "The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats." dans: International journal of molecular medicine, Vol. 38, Issue 3, pp. 767-75, (2016) (PubMed).

    Sun, Zhang, Cui, Chen, Xie, Zhou, Liu, Peng, Zhang: "High mobility group box-1 and its clinical value in breast cancer." dans: OncoTargets and therapy, Vol. 8, pp. 413-9, (2015) (PubMed).

    Zhang, He, Wang, Zhou, Ma: "Omega-3 polyunsaturated fatty acids inhibit the increase in cytokines and chemotactic factors induced in vitro by lymph fluid from an intestinal ischemia-reperfusion injury model." dans: Nutrition (Burbank, Los Angeles County, Calif.), Vol. 31, Issue 3, pp. 508-14, (2015) (PubMed).

    Luan, Kan, Xu, Lv, Jiang: "Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response." dans: Journal of neuroinflammation, Vol. 10, pp. 28, (2013) (PubMed).

    Zhao, Hu, Sun, Sun: "The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation." dans: Developmental and comparative immunology, Vol. 35, Issue 10, pp. 1052-8, (2011) (PubMed).

    Jiang, Fu, Tian, Zhu, Hou: "Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo." dans: Neuroscience, Vol. 192, pp. 572-9, (2011) (PubMed).

  • Antigène
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Autre désignation
    HMGB1 (HMGB1 Produits)
    Synonymes
    anticorps HMG1, anticorps HMG3, anticorps SBP-1, anticorps DEF, anticorps HMG-1, anticorps Hmg1, anticorps amphoterin, anticorps p30, anticorps hmgb1, anticorps ik:tdsubc_1a5, anticorps wu:fb23c02, anticorps xx:tdsubc_1a5, anticorps zgc:56110, anticorps zgc:77104, anticorps hmg-1, anticorps hmg3, anticorps sbp-1, anticorps hmg1, anticorps HMGB1, anticorps Ac2-008, anticorps high mobility group box 1, anticorps high-mobility group box 1, anticorps high mobility group box 1a, anticorps high mobility group box 1 L homeolog, anticorps high mobility group protein B1, anticorps HMGB1, anticorps Hmgb1, anticorps hmgb1, anticorps hmgb1a, anticorps hmgb1.L, anticorps LOC100359149
    Sujet

    Synonyms: HMG1, HMG3, SBP-1, High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1

    Background: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).

    ID gène
    3146
    UniProt
    P09429
    Pathways
    Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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