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TCF7L2 anticorps (AA 401-550)

TCF7L2 Reactivité: Rat ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN674349
  • Antigène Voir toutes TCF7L2 Anticorps
    TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
    Épitope
    • 14
    • 11
    • 11
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-550
    Reactivité
    • 49
    • 30
    • 29
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Rat
    Hôte
    • 61
    • 7
    Lapin
    Clonalité
    • 52
    • 16
    Polyclonal
    Conjugué
    • 29
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TCF7L2 est non-conjugé
    Application
    • 47
    • 24
    • 18
    • 13
    • 12
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Cow,Pig,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human TCF7L2
    Isotype
    IgG
    Top Product
    Discover our top product TCF7L2 Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
    Autre désignation
    TCF7L2 (TCF7L2 Produits)
    Synonymes
    anticorps TCF4B, anticorps TCF4E, anticorps Tcf-4, anticorps Tcf4, anticorps mTcf-4B, anticorps mTcf-4E, anticorps tcf4, anticorps XTCF-4, anticorps tcf4e, anticorps TCF4, anticorps TCF-4, anticorps TCFL2, anticorps transcription factor 7 like 2, anticorps transcription factor 7-like 2, anticorps transcription factor 7 like 2, T cell specific, HMG box, anticorps transcription factor 7 like 2 L homeolog, anticorps transcription factor 7-like 2 (T-cell specific, HMG-box), anticorps TCF7L2, anticorps LOC100545943, anticorps Tcf7l2, anticorps tcf7l2, anticorps tcf7l2.L
    Sujet

    Synonyms: TCF4, TCF-4, Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, hTCF-4, TCF7L2

    Background: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

    ID gène
    6934
    UniProt
    Q9NQB0
    Pathways
    Signalisation WNT, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
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