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Ki-67 anticorps (AA 1201-1300)

MKI67 Reactivité: Humain, Souris, Rat, Lapin, Chévre ELISA, IHC (p), IF (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN677858
  • Antigène Voir toutes Ki-67 (MKI67) Anticorps
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    Épitope
    • 16
    • 16
    • 16
    • 16
    • 15
    • 14
    • 12
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1201-1300
    Reactivité
    • 215
    • 95
    • 60
    • 15
    • 14
    • 5
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Lapin, Chévre
    Hôte
    • 158
    • 52
    • 12
    • 3
    Lapin
    Clonalité
    • 149
    • 74
    Polyclonal
    Conjugué
    • 96
    • 15
    • 14
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp Ki-67 est non-conjugé
    Application
    • 92
    • 89
    • 66
    • 65
    • 55
    • 51
    • 42
    • 33
    • 30
    • 16
    • 15
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Ki67
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Luo, Kong, Pei, Jin, Liu: "LncRNA CASC2 inhibits proliferation and migration of adenocarcinoma cells via miR-4735-3p and mTOR." dans: Journal of cellular biochemistry, (2018) (PubMed).

    Dong, Ma, Wang, Han, Zou, Wu, Zang, Zhuang: "YY1 promotes HDAC1 expression and decreases sensitivity of hepatocellular carcinoma cells to HDAC inhibitor." dans: Oncotarget, Vol. 8, Issue 25, pp. 40583-40593, (2018) (PubMed).

    Wu, Liu, Liu, Yan, Tang, Cui, Zhao, Shi, Hao, Yu, Qian: "A retrospective, single-center cohort study on 65 patients with primary retroperitoneal liposarcoma." dans: Oncology letters, Vol. 15, Issue 2, pp. 1799-1810, (2018) (PubMed).

    Thompson, Rahim, Arnold, Hielscher: "Loss of caveolin-1 alters extracellular matrix protein expression and ductal architecture in murine mammary glands." dans: PLoS ONE, Vol. 12, Issue 2, pp. e0172067, (2017) (PubMed).

    He, Chen, Yuan, Zhao, Chen, Wang, Li: "Tumor pH-Responsive Release of Drug-Conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy." dans: ACS applied materials & interfaces, Vol. 9, Issue 38, pp. 32534-32544, (2017) (PubMed).

    Liang, Fang, Yang, Song: "Silencing of CEMIP suppresses Wnt/β-catenin/Snail signaling transduction and inhibits EMT program of colorectal cancer cells." dans: Acta histochemica, Vol. 120, Issue 1, pp. 56-63, (2017) (PubMed).

    Antognelli, Gambelunghe, Muzi, Talesa et al.: "Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica ..." dans: Free radical biology & medicine, Vol. 92, pp. 110-25, (2016) (PubMed).

    Li, Zhu, Qiu: "Constructing aptamer anchored nanovesicles for enhanced tumor penetration and cellular uptake of water soluble chemotherapeutics." dans: Acta biomaterialia, Vol. 35, pp. 269-79, (2016) (PubMed).

    Drel, Tan, Barnes, Gorin, Lee, Wagner: "Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3026-38, (2016) (PubMed).

    Ma, Jia, Zhang: "IL-17 promotes keratinocyte proliferation via the downregulation of C/EBPα." dans: Experimental and therapeutic medicine, Vol. 11, Issue 2, pp. 631-636, (2016) (PubMed).

    Yang, Li, Zhu, Wang, Chen, Bai: "Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-?B signaling pathway in H22 tumor-bearing mice." dans: European journal of pharmacology, Vol. 754, pp. 105-14, (2015) (PubMed).

    Olianas, Dedoni, Onali et al.: "Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 ..." dans: Biochemical pharmacology, Vol. 95, Issue 4, pp. 311-23, (2015) (PubMed).

    Zhang, Song, Pang, Zhang, Wan, Yuan, Wu, Liu: "Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice." dans: World journal of gastroenterology : WJG, Vol. 21, Issue 14, pp. 4195-209, (2015) (PubMed).

    Luo, Chen, Zhang, Chen, Li: "Pharmacokinetics and antitumor efficacy of micelles assembled from multiarmed amphiphilic copolymers with drug conjugates in comparison with drug-encapsulated micelles." dans: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 98, pp. 9-19, (2015) (PubMed).

    Kim, Lim, Kim, Kim, Kim, Tian, Park, Park, Choung: "The oncoprotein, gankyrin, is up-regulated in middle ear cholesteatoma." dans: Acta oto-laryngologica, Vol. 134, Issue 3, pp. 238-43, (2014) (PubMed).

    Ma, Yu, He, Xu, Wu, Xia, Guo, Wang, Ye, Zhang, Tao: "Involvement of c-KIT mutation in the development of gastrointestinal stromal tumors through proliferation promotion and apoptosis inhibition." dans: OncoTargets and therapy, Vol. 7, pp. 637-43, (2014) (PubMed).

    Ye, Zheng, Fan, Qin, Li, Tang, Ai, Zhang, Bian, Dang, Huang, Zhou, Zhou, Xiong, Yan, Ma, Li: "Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice." dans: PLoS ONE, Vol. 9, Issue 7, pp. e103298, (2014) (PubMed).

    Li, Li, Yi, Luo, Guo, Pan, Gu: "Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-responsive anti-cancer agent." dans: Biomaterials, Vol. 35, Issue 35, pp. 9529-45, (2014) (PubMed).

    Luo, Zhang, Chen, Wei, Zhang, Li: "Antimetastasis and antitumor efficacy promoted by sequential release of vascular disrupting and chemotherapeutic agents from electrospun fibers." dans: International journal of pharmaceutics, Vol. 475, Issue 1-2, pp. 438-449, (2014) (PubMed).

    Pan, She, Guo, Luo, Yi, Gu: "PEGylated dendritic diaminocyclohexyl-platinum (II) conjugates as pH-responsive drug delivery vehicles with enhanced tumor accumulation and antitumor efficacy." dans: Biomaterials, Vol. 35, Issue 38, pp. 10080-92, (2014) (PubMed).

  • Antigène
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    Autre désignation
    Ki-67 proliferation Marker (MKI67 Produits)
    Synonymes
    anticorps MKI67, anticorps kia, anticorps mki67, anticorps MGC132156, anticorps D630048A14Rik, anticorps Ki-67, anticorps Ki67, anticorps KIA, anticorps MIB-1, anticorps marker of proliferation Ki-67, anticorps marker of proliferation Ki-67 L homeolog, anticorps marker of proliferation Ki-67 S homeolog, anticorps antigen identified by monoclonal antibody Ki 67, anticorps antigen identified by monoclonal antibody Ki-67, anticorps nucleolar protein interacting with the FHA domain of MKI67, anticorps MKI67, anticorps mki67, anticorps mki67.L, anticorps mki67.S, anticorps Mki67, anticorps NIFK
    Sujet

    Synonyms: KIA, MIB-, MIB-1, PPP1R15, Antigen KI-67, MKI67

    Background: Proliferation Marker Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

    ID gène
    4288
    UniProt
    P46013
    Pathways
    Glycosaminoglycan Metabolic Process
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