SCNN1A anticorps (AA 201-300)

N° du produit ABIN682243

Détail du produit anti-SCNN1A anticorps

Antigène: SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))

Épitope: AA 201-300

Reactivité: Rat, Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCNN1A est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Alpha-ENaC

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-SCNN1A (ABIN682243)

Scortegagna, Berthon, Settas, Giannakou, Garcia, Li, James, Liddington, Vilches-Moure, Stratakis, Ronai: "The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion." dans: JCI insight, Vol. 2, Issue 23, (2019) (PubMed).

Yamamoto, Hotta, Maeda, Kataoka, Maeda, Hamakawa, Sasaki, Yasui, Asai, Kimura: "Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium." dans: Journal of pharmacological sciences, Vol. 130, Issue 4, pp. 219-25, (2016) (PubMed).

Détails sur SCNN1A

Antigène: SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))

Autre désignation: Alpha-ENaC (SCNN1A Produits)

Synonymes: anticorps BESC2, anticorps ENaCa, anticorps ENaCalpha, anticorps SCNEA, anticorps SCNN1, anticorps ENaC, anticorps Scnn1, anticorps mENaC, anticorps SCNN1A, anticorps alphaxENaC, anticorps besc2, anticorps enaca, anticorps scnn1, anticorps ENAC, anticorps sodium channel epithelial 1 alpha subunit, anticorps sodium channel, nonvoltage-gated 1 alpha, anticorps sodium channel, non voltage gated 1 alpha subunit L homeolog, anticorps Scnn1a, anticorps SCNN1A, anticorps scnn1a.L

Sujet:

Synonyms: BESC2, ENaCa, SCNEA, SCNN1, ENaCalpha, Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, SCNN1A

Background: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

ID gène: 6337

UniProt: P37088