VDAC1 anticorps (AA 85-190)

N° du produit ABIN686872

Détail du produit anti-VDAC1 anticorps

Antigène: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Épitope: AA 85-190

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VDAC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: May detect VDAC2 due to sequence similarity

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human VDAC1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-VDAC1 (ABIN686872)

Wang, Lin, Zhang, Liu, Tan, Ma: "Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway." dans: European journal of pharmacology, Vol. 797, pp. 115-123, (2017) (PubMed).

Hui, Lu, Han, Zhou, Liu, Li, Jin: "Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats." dans: Acta histochemica, Vol. 119, Issue 4, pp. 392-399, (2017) (PubMed).

Tan, Chen, Ma: "Penehyclidine hydrochloride post-conditioning reduces ischemia/reperfusion-induced cardiomyocyte apoptosis in rats." dans: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 4272-4278, (2017) (PubMed).

Xing, Yuan, Xu, Gu, Liang, Lu: "Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model." dans: Environmental toxicology and pharmacology, Vol. 40, Issue 2, pp. 592-9, (2015) (PubMed).

Manczak, Reddy: "Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease." dans: Human molecular genetics, Vol. 21, Issue 23, pp. 5131-46, (2012) (PubMed).

Détails sur VDAC1

Antigène: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Autre désignation: VDAC (VDAC1 Produits)

Synonymes: anticorps vdac1, anticorps VDAC1, anticorps 5076, anticorps ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, anticorps ATVDAC1, anticorps T22N4.9, anticorps T22N4_9, anticorps voltage dependent anion channel 1, anticorps PORIN, anticorps VDAC-1, anticorps AL033343, anticorps Vdac5, anticorps fa13f11, anticorps wu:fa13f11, anticorps zgc:85830, anticorps voltage-dependent anion channel 1 S homeolog, anticorps voltage-dependent anion channel 1, anticorps voltage dependent anion channel 1, anticorps vdac1.S, anticorps vdac1, anticorps VDAC1, anticorps Vdac1

Sujet:

Synonyms: PORIN, VDAC-1, Voltage-dependent anion-selective channel protein 1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC1, VDAC

Background: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

ID gène: 7416

UniProt: P21796