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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) (AA 1051-1280) anticorps (HRP)

ABCB1B Reactivité: Humain, Souris, Rat ELISA, WB, IHC (fro), IHC (p) Hôte: Lapin Polyclonal HRP
N° du produit ABIN686986
  • Antigène Voir toutes ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Anticorps
    ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)
    Épitope
    • 15
    • 8
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1280
    Reactivité
    • 31
    • 23
    • 23
    • 4
    • 4
    • 4
    • 4
    Humain, Souris, Rat
    Hôte
    • 34
    • 13
    Lapin
    Clonalité
    • 34
    • 13
    Polyclonal
    Conjugué
    • 13
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    HRP
    Application
    • 22
    • 19
    • 18
    • 14
    • 14
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MDR1
    Isotype
    IgG
    Top Product
    Discover our top product ABCB1B Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)
    Autre désignation
    MDR1 (ABCB1B Produits)
    Synonymes
    anticorps ABC20, anticorps CD243, anticorps CLCS, anticorps GP170, anticorps MDR1, anticorps P-GP, anticorps PGY1, anticorps Abcb1, anticorps Mdr1, anticorps Mdr1b, anticorps Pgy-1, anticorps Pgy1, anticorps mdr, anticorps ATP binding cassette subfamily B member 1, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 1B, anticorps ATP-binding cassette, subfamily B (MDR/TAP), member 1B, anticorps ABCB1, anticorps Abcb1b
    Sujet

    Synonyms: P-Glycoprotein, Multi Drug Resistance Associated Protein, ABCB1, ATP-binding cassette sub-family B MDR/TAP, member 1, ABC20, CD243, CD243 antigen, CLCS, Multidrug resistance protein 1, P glycoprotein 1, p-GP, gp170, P gp, PGY1.

    Background: P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

    ID gène
    5243
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