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CFTR anticorps (AA 258-385)

CFTR Reactivité: Humain ISt, IHC (f) Hôte: Souris Monoclonal CFTR-1785 unconjugated
N° du produit ABIN6939088
  • Antigène Voir toutes CFTR Anticorps
    CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))
    Épitope
    • 38
    • 7
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 258-385
    Reactivité
    • 107
    • 38
    • 26
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 60
    • 47
    Souris
    Clonalité
    • 70
    • 37
    Monoclonal
    Conjugué
    • 58
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CFTR est non-conjugé
    Application
    • 63
    • 46
    • 46
    • 42
    • 22
    • 17
    • 13
    • 9
    • 9
    • 2
    • 2
    • 1
    • 1
    Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
    Réactivité croisée (Details)
    Human,
    Purification
    200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
    Immunogène
    Recombinant fragment (around aa 258-385) of human CFTR protein (exact sequence is proprietary)
    Clone
    CFTR-1785
    Isotype
    IgG2b
    Top Product
    Discover our top product CFTR Anticorps primaire
  • Indications d'application

    Positive Control: MOLT-4 cells. Pancreas, Kidney or Placenta.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Date de péremption
    24 months
  • Antigène
    CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))
    Autre désignation
    CFTR (CFTR Produits)
    Synonymes
    anticorps ABC35, anticorps ABCC7, anticorps CF, anticorps CFTR/MRP, anticorps MRP7, anticorps TNR-CFTR, anticorps dJ760C5.1, anticorps CFTR, anticorps AW495489, anticorps Abcc7, anticorps RGD1561193, anticorps abc35, anticorps abcc7, anticorps cftr/mrp, anticorps mrp7, anticorps tnr-cftr, anticorps xcftr, anticorps si:dkey-270i2.2, anticorps cystic fibrosis transmembrane conductance regulator, anticorps cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), anticorps CFTR, anticorps cftr-A, anticorps Cftr, anticorps cftr
    Sujet
    ABC35, ATP Binding Cassette Superfamily C Member 7 (ABCC7), cAMP-dependent chloride channel, CFTR, CFTR/MRP, Channel conductance-controlling ATPase, Cystic Fibrosis Transmembrane Conductance Regulator, MRP7, TNR CFTR,CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
    Cellular localisation: Cell Surface and Cytoplasmic
    Poids moléculaire
    165-170kDa
    ID gène
    1080, 489786, 621460
    UniProt
    P13569
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