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Insulin anticorps

INS Reactivité: Humain, Porc, Souris, Boeuf (Vache), Lapin IHC, StM Hôte: Souris Monoclonal E2-E3-same as INS04 unconjugated
N° du produit ABIN6939791
  • Antigène Voir toutes Insulin (INS) Anticorps
    Insulin (INS)
    Reactivité
    • 190
    • 106
    • 91
    • 76
    • 70
    • 40
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Porc, Souris, Boeuf (Vache), Lapin
    Hôte
    • 137
    • 86
    • 13
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 144
    • 98
    Monoclonal
    Conjugué
    • 121
    • 20
    • 15
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Insulin est non-conjugé
    Application
    • 83
    • 74
    • 67
    • 67
    • 66
    • 55
    • 47
    • 39
    • 26
    • 24
    • 21
    • 17
    • 16
    • 11
    • 9
    • 9
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
    Purification
    Purified by Protein A/G
    Immunogène
    Purified pig insulin, conjugated to KLH
    Clone
    E2-E3-same as INS04
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product INS Anticorps primaire
  • Indications d'application

    Positive Control: MIA PaCa-2 cells. Pancreas.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Insulin (INS)
    Autre désignation
    INS (INS Produits)
    Synonymes
    anticorps IDDM2, anticorps ILPR, anticorps IRDN, anticorps MODY10, anticorps ins1, anticorps xins, anticorps ins1-a, anticorps Insulin, anticorps AA986540, anticorps Ins-2, anticorps InsII, anticorps Mody, anticorps Mody4, anticorps proinsulin, anticorps zgc:109842, anticorps igf2-A, anticorps ins, anticorps ins-a, anticorps ins-b, anticorps insulin, anticorps insulin precursor, anticorps insulin II, anticorps preproinsulin, anticorps insulin L homeolog, anticorps insulin S homeolog, anticorps INS, anticorps INS-IGF2, anticorps ins, anticorps Ins, anticorps PIN, anticorps Ins2, anticorps ins.L, anticorps ins.S
    Poids moléculaire
    6kDa
    ID gène
    3630
    UniProt
    P01308
    Pathways
    Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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