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MUC1 anticorps

MUC1 Reactivité: Humain, Souris IHC, WB, ELISA, IF, FACS, Coat, StM Hôte: Souris Monoclonal MUC1-955 unconjugated
N° du produit ABIN6940096
  • Antigène Voir toutes MUC1 Anticorps
    MUC1 (Mucin 1 (MUC1))
    Reactivité
    • 275
    • 57
    • 30
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 198
    • 90
    • 2
    • 1
    Souris
    Clonalité
    • 176
    • 110
    • 5
    Monoclonal
    Conjugué
    • 147
    • 26
    • 16
    • 12
    • 11
    • 11
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MUC1 est non-conjugé
    Application
    • 141
    • 137
    • 102
    • 85
    • 74
    • 48
    • 26
    • 25
    • 24
    • 20
    • 19
    • 14
    • 13
    • 12
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat), Staining Methods (StM)
    Specificité
    This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in 90 % breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
    Purification
    Purified by Protein A/G
    Immunogène
    Human milk-fat globule membranes (HMFGM)
    Clone
    MUC1-955
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MUC1 Anticorps primaire
  • Indications d'application

    Positive Control: MCF-7 or MDA-231 cells. Breast, colon, ovarian, endometrial carcinoma.

    Known Application: ELISA (For coating use Ab at 2-5 μg/mL, order Ab without BSA) (Very good capturing Ab), Western Blot (0.5-2 μg/mL), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (0.25-0.5 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    MUC1 (Mucin 1 (MUC1))
    Autre désignation
    MUC1 (MUC1 Produits)
    Synonymes
    anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1
    Poids moléculaire
    265-400kDa
    ID gène
    4582
    UniProt
    P15941
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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