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MUC1 anticorps

MUC1 Reactivité: Humain IHC, StM Hôte: Souris Monoclonal MUC1-845 unconjugated
N° du produit ABIN6940105
  • Antigène Voir toutes MUC1 Anticorps
    MUC1 (Mucin 1 (MUC1))
    Reactivité
    • 276
    • 58
    • 30
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 198
    • 91
    • 2
    • 1
    Souris
    Clonalité
    • 176
    • 111
    • 5
    Monoclonal
    Conjugué
    • 148
    • 26
    • 16
    • 12
    • 11
    • 11
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MUC1 est non-conjugé
    Application
    • 142
    • 138
    • 103
    • 86
    • 75
    • 48
    • 26
    • 25
    • 24
    • 20
    • 19
    • 14
    • 13
    • 13
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    In Western blotting, it recognizes proteins in MW range of 265-400 kDa, identified as different glycoforms of EMA. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions.In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
    Purification
    Purified by Protein A/G
    Immunogène
    Human milk-fat globule membranes (HMFGM)
    Clone
    MUC1-845
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MUC1 Anticorps primaire
  • Indications d'application

    Positive Control: MCF-7 or MDA-231 cells. Breast, colon, ovarian, endometrial carcinoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    MUC1 (Mucin 1 (MUC1))
    Autre désignation
    MUC1 (MUC1 Produits)
    Synonymes
    anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1
    Poids moléculaire
    265-400kDa
    ID gène
    4582
    UniProt
    P15941
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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