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Perforin 1 anticorps (AA 413-552)

PRF1 Reactivité: Humain IHC, ELISA, Coat Hôte: Souris Monoclonal PRF1-2468 unconjugated
N° du produit ABIN6940387
  • Antigène Voir toutes Perforin 1 (PRF1) Anticorps
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Épitope
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 413-552
    Reactivité
    • 86
    • 26
    • 11
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 57
    • 47
    • 4
    Souris
    Clonalité
    • 58
    • 50
    Monoclonal
    Conjugué
    • 59
    • 13
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Perforin 1 est non-conjugé
    Application
    • 51
    • 40
    • 30
    • 25
    • 16
    • 10
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Coating (Coat)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant human Perforin-1 protein fragment (around aa 413-552) (exact sequence is proprietary)
    Clone
    PRF1-2468
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product PRF1 Anticorps primaire
  • Indications d'application

    Positive Control: HDLM-2 cells. Human spleen tissue (IHC).

    Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Autre désignation
    PRF1 (PRF1 Produits)
    Synonymes
    anticorps FLH2, anticorps HPLH2, anticorps P1, anticorps PFN1, anticorps PFP, anticorps PRF1, anticorps Pfn, anticorps Pfp, anticorps Prf-1, anticorps Cyta, anticorps RATCYTA, anticorps LOC443187, anticorps perforin, anticorps prf1, anticorps cytolysin, anticorps perforin-1, anticorps perforin-1-like, anticorps perforin 1, anticorps perforin 1 (pore forming protein), anticorps perforin, anticorps perforin 1 L homeolog, anticorps PRF1, anticorps Prf1, anticorps LOC443187, anticorps prf1, anticorps prf1.L
    Sujet
    Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
    Poids moléculaire
    75kDa
    ID gène
    5551
    UniProt
    P14222
    Pathways
    Apoptose, Caspase Cascade in Apoptosis
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