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MAML3 anticorps

MAML3 Reactivité: Humain ISt, IHC, StM Hôte: Souris Monoclonal MAML3-1303 unconjugated
N° du produit ABIN6940389
  • Antigène Voir toutes MAML3 Anticorps
    MAML3 (Mastermind-Like 3 (MAML3))
    Reactivité
    • 42
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 29
    • 13
    Souris
    Clonalité
    • 30
    • 12
    Monoclonal
    Conjugué
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAML3 est non-conjugé
    Application
    • 15
    • 13
    • 13
    • 13
    • 12
    • 9
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunostaining (ISt), Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant human MAML3 protein fragment
    Clone
    MAML3-1303
    Isotype
    IgG1 kappa
  • Indications d'application

    Positive Control: MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    MAML3 (Mastermind-Like 3 (MAML3))
    Autre désignation
    MAML3 (MAML3 Produits)
    Synonymes
    anticorps AV234550, anticorps BC049812, anticorps Mam-2, anticorps mKIAA1816, anticorps Glrp1, anticorps CAGH3, anticorps ERDA3, anticorps GDN, anticorps MAM-2, anticorps MAM2, anticorps TNRC3, anticorps mastermind like 3 (Drosophila), anticorps mastermind-like transcriptional coactivator 3, anticorps mastermind like transcriptional coactivator 3, anticorps Maml3, anticorps MAML3
    Sujet
    MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
    Poids moléculaire
    150-170kDa
    ID gène
    55534
    UniProt
    Q96JK9
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