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Recombinant Bcl-2 anticorps

BCL2 Reactivité: Humain WB, IHC, StM Hôte: Lapin Monoclonal BCL2-2210R unconjugated Recombinant Antibody
N° du produit ABIN6940502
  • Antigène Voir toutes Bcl-2 (BCL2) Anticorps
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 453
    • 190
    • 187
    • 38
    • 34
    • 22
    • 22
    • 19
    • 17
    • 16
    • 12
    • 5
    • 5
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 357
    • 124
    • 6
    • 2
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 354
    • 137
    Monoclonal
    Conjugué
    • 217
    • 35
    • 34
    • 25
    • 25
    • 15
    • 14
    • 13
    • 11
    • 11
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Bcl-2 est non-conjugé
    Application
    • 395
    • 201
    • 168
    • 122
    • 107
    • 103
    • 92
    • 75
    • 64
    • 33
    • 29
    • 25
    • 18
    • 8
    • 8
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant full-length human bcl-2 protein
    Clone
    BCL2-2210R
    Isotype
    IgG
    Top Product
    Discover our top product BCL2 Anticorps primaire
  • Indications d'application

    Positive Control: Jurkat, K562, HL-60 or HeLa cells. Tonsil or follicular lymphomas.

    Known Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 1 mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Autre désignation
    BCL2 (BCL2 Produits)
    Synonymes
    anticorps Bcl-2, anticorps PPP1R50, anticorps bcl-2, anticorps AW986256, anticorps C430015F12Rik, anticorps D630044D05Rik, anticorps D830018M01Rik, anticorps BCL-2, anticorps Bcl2, anticorps BCL2, apoptosis regulator, anticorps B cell leukemia/lymphoma 2, anticorps B-cell CLL/lymphoma 2a, anticorps B-cell CLL/lymphoma 2 protein, anticorps BCL2, anticorps Bcl2, anticorps bcl2a, anticorps BCL-2
    Poids moléculaire
    25-26kDa
    ID gène
    596
    UniProt
    P10415
    Pathways
    Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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