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Recombinant BCL6 anticorps (AA 256-389)

BCL6 Reactivité: Humain IHC, StM Hôte: Lapin Monoclonal BCL6-2497R unconjugated Recombinant Antibody
N° du produit ABIN6940532
  • Antigène Voir toutes BCL6 Anticorps
    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
    Type d'anticorp
    Recombinant Antibody
    Épitope
    • 27
    • 22
    • 15
    • 11
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 256-389
    Reactivité
    • 144
    • 76
    • 26
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 89
    • 53
    • 2
    • 1
    Lapin
    Clonalité
    • 79
    • 66
    Monoclonal
    Conjugué
    • 68
    • 13
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BCL6 est non-conjugé
    Application
    • 91
    • 46
    • 36
    • 33
    • 33
    • 18
    • 17
    • 13
    • 13
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    Recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
    Clone
    BCL6-2497R
    Isotype
    IgG
    Top Product
    Discover our top product BCL6 Anticorps primaire
  • Indications d'application

    Positive Control: Raji or Ramos cells. Tonsil or Hodgkin's lymphoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
    Autre désignation
    BCL6 (BCL6 Produits)
    Synonymes
    anticorps bcl5, anticorps laz3, anticorps bcl6a, anticorps znf51, anticorps zbtb27, anticorps MGC132260, anticorps Bcl5, anticorps BCL5, anticorps BCL6A, anticorps LAZ3, anticorps ZBTB27, anticorps ZNF51, anticorps B-cell CLL/lymphoma 6 L homeolog, anticorps B-cell CLL/lymphoma 6, anticorps B cell leukemia/lymphoma 6, anticorps bcl6.L, anticorps bcl6, anticorps BCL6, anticorps Bcl6
    Poids moléculaire
    95kDa
    ID gène
    604
    UniProt
    P41182
    Pathways
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
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