C1QB anticorps (AA 41-188)

N° du produit ABIN6940772

Détail du produit anti-C1QB anticorps

Antigène: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Épitope: AA 41-188

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C1QB est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment (around aa 41-188) of human C1QB protein (exact sequence is proprietary)

Clone: C1QB-2966

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Human liver, kidney or brain (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur C1QB

Antigène: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Autre désignation: C1QB (C1QB Produits)

Synonymes: anticorps complement C1q B chain, anticorps complement component 1, q subcomponent, beta polypeptide, anticorps C1QB, anticorps C1qb

Sujet: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

Poids moléculaire: 26-29kDa

ID gène: 713

UniProt: P02746

Pathways: Système du Complément