NPC1 anticorps

N° du produit ABIN6944307

Détail du produit anti-NPC1 anticorps

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp NPC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Synthetic peptide within human NPC1 aa 1250-1270

Clone: 1B12

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NPC1

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Autre désignation: NPC1 (NPC1 Produits)

Synonymes: anticorps NPC, anticorps 9130221N23Rik, anticorps Gm243, anticorps Cdig2, anticorps im:7149020, anticorps wu:fb53a12, anticorps wu:fc29a12, anticorps A430089E03Rik, anticorps C85354, anticorps D18Ertd139e, anticorps D18Ertd723e, anticorps lcsd, anticorps nmf164, anticorps spm, anticorps NPC intracellular cholesterol transporter 1, anticorps NPC1 like intracellular cholesterol transporter 1, anticorps Niemann-Pick disease, type C1, anticorps Niemann-Pick C1 protein, anticorps NPC1, anticorps Npc1l1, anticorps Npc1, anticorps npc1, anticorps LOC579887

Sujet:

Synonyms: NPC intracellular cholesterol transporter 1, Niemann Pick C1 protein, NPC1, POGZ, SLC65A1

Background: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Acts as an endosomal entry receptor for ebolavirus.

ID gène: 4864

UniProt: O15118