PAK2 anticorps

N° du produit ABIN6944411

Détail du produit anti-PAK2 anticorps

Antigène: PAK2 (P21-Activated Kinase 2 (PAK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PAK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human PAK2 aa 1-200

Clone: 6B4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PAK2

Antigène: PAK2 (P21-Activated Kinase 2 (PAK2))

Autre désignation: PAK2 (PAK2 Produits)

Synonymes: anticorps PAK65, anticorps PAKgamma, anticorps gamma-PAK, anticorps 5330420P17Rik, anticorps A130002K10Rik, anticorps AI836325, anticorps D16Ertd269e, anticorps PAK-2, anticorps mKIAA4182, anticorps pak2, anticorps cb422, anticorps kinase, anticorps zgc:91798, anticorps wu:fb71h01, anticorps si:dz198m22.1, anticorps pak65, anticorps pakgamma, anticorps PAKI, anticorps Pak3, anticorps CH73-159L23.1, anticorps wu:fc52b03, anticorps zgc:113857, anticorps p21 (RAC1) activated kinase 2, anticorps p21 protein (Cdc42/Rac)-activated kinase 2, anticorps p21 protein (Cdc42/Rac)-activated kinase 2a, anticorps p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog, anticorps p21 protein (Cdc42/Rac)-activated kinase 2b, anticorps PAK2, anticorps Pak2, anticorps pak2a, anticorps pak2.S, anticorps pak2b

Sujet:

Synonyms: Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, p58, PAK-2p27, PAK-2p34, C-t-PAK2, PAK-2, p27, p34, PAK2

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

ID gène: 5062

UniProt: Q13177

Pathways: Signalisation MAPK, Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha