PIWIL1 anticorps

N° du produit ABIN6944551

Détail du produit anti-PIWIL1 anticorps

Antigène: PIWIL1 (Piwi-Like 1 (PIWIL1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PIWIL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human PIWIL1 aa 700-850

Clone: 12C7

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PIWIL1

Antigène: PIWIL1 (Piwi-Like 1 (PIWIL1))

Autre désignation: PIWIL1 (PIWIL1 Produits)

Synonymes: anticorps ziwi, anticorps PIWI, anticorps HIWI, anticorps MIWI, anticorps piwi like RNA-mediated gene silencing 1, anticorps PIWI-like protein 1, anticorps putative PIWI-like protein 1, anticorps putative argonaut-like protein, anticorps piwi-like RNA-mediated gene silencing 1, anticorps PIWIL1, anticorps Tb10.70.5520, anticorps LINJ_21_0470, anticorps LBRM_21_0470, anticorps piwil1, anticorps Piwil1

Sujet:

Synonyms: Piwi-like protein 1, PIWIL1, HIWI., MIWI, CT80.1.

Background: Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Required to sequester RNF8 in the cytoplasm until late spermatogenesis, RNF8 being released upon ubiquitination and degradation of PIWIL1.

ID gène: 9271

UniProt: Q96J94