CYP27B1 anticorps (AA 1-100) (Biotin)

N° du produit ABIN6942772

Détail du produit anti-CYP27B1 anticorps (Biotin)

Antigène: CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))

Épitope: AA 1-100

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP27B1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CYP27B1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CYP27B1

Antigène: CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))

Autre désignation: CYP27B1 (CYP27B1 Produits)

Synonymes: anticorps cp2b, anticorps cyp1, anticorps cyp1alpha, anticorps cyp27b, anticorps p450c1, anticorps pddr, anticorps vdd1, anticorps vddr, anticorps vddri, anticorps vdr, anticorps CP2B, anticorps CYP1, anticorps CYP1alpha, anticorps CYP27B, anticorps P450c1, anticorps PDDR, anticorps VDD1, anticorps VDDR, anticorps VDDRI, anticorps VDR, anticorps Cyp40, anticorps Cp2b, anticorps Cyp1, anticorps Cyp27b, anticorps Pddr, anticorps Vdd1, anticorps Vddr, anticorps VddrI, anticorps Vdr, anticorps cytochrome P450 family 27 subfamily B member 1, anticorps cytochrome P450, family 27, subfamily B, polypeptide 1, anticorps cytochrome P450, family 27, subfamily b, polypeptide 1, anticorps cyp27b1, anticorps CYP27B1, anticorps Cyp27b1

Sujet:

Synonyms: 1alpha(OH)ase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, 25-OHD-1 alpha-hydroxylase, Calcidiol 1-monooxygenase, CP27B_HUMAN, CP2B, CYP1, CYP1ALPHA, CYP27B, Cyp27b1, Cytochrome p450 27B1, Cytochrome p450 27B13, Cytochrome P450 family 27 subfamily B polypeptide 1, Cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, mitochondrial, P450C1 alpha, P450c1, P450C1-alpha, P450VD1-alpha, PDDR, VD3 1A hydroxylase, VDD1, VDDR, VDDR I, VDDRI, VDR.

Background: The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP27B1, a 508-amino acid protein that belongs to the XXVIIB subfamily of the cytochrome P450 family, localizes to the mitochondrion and is expressed in the kidney. The CYP27B1 protein catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) and functions in calcium metabolism, normal bone growth, and tissue differentiation. Mutations in the gene which encodes for CYP27B1 cause vitamin D-dependent rickets type 1 (VDDR-1), also designated pseudovitamin D deficiency rickets (PDDR), an autosomal recessive disease characterized by early onset of rickets with hypocalcemia and muscle weakness.

ID gène: 1594

UniProt: O15528

Pathways: Metabolism of Steroid Hormones and Vitamin D