RPE65 anticorps

N° du produit ABIN6944796

Détail du produit anti-RPE65 anticorps

Antigène: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RPE65 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Human RPE65 aa 450 to the C-terminus

Clone: 2C1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur RPE65

Antigène: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Autre désignation: RPE65 (RPE65 Produits)

Synonymes: anticorps LCA2, anticorps RP20, anticorps mRPE65, anticorps rd12, anticorps sRPE65, anticorps 65kDa, anticorps A930029L06Rik, anticorps Mord1, anticorps DRPE65, anticorps RPE65, anticorps anon-WO0148162.1, anticorps anon-WO0148163.1, anticorps beta-diox, anticorps DmelCG9347, anticorps CG9347, anticorps MGC52887, anticorps MGC154296, anticorps MGC85437, anticorps rpe65, anticorps RPE56c, anticorps si:ch211-198n5.12, anticorps 13cIMH, anticorps RPE56b, anticorps rpepb, anticorps si:ch211-198n5.5, anticorps wu:fc74c09, anticorps zgc:110538, anticorps RPE56a, anticorps rpepa, anticorps zgc:73213, anticorps RPE65, retinoid isomerohydrolase, anticorps retinal pigment epithelium 65, anticorps neither inactivation nor afterpotential B, anticorps retinal pigment epithelium-specific protein 65kDa S homeolog, anticorps retinal pigment epithelium-specific protein 65kDa L homeolog, anticorps RPE65 homolog, anticorps retinal pigment epithelium-specific protein 65kDa, anticorps retinal pigment epithelium-specific protein 65c, anticorps retinal pigment epithelium-specific protein 65b, anticorps retinal pigment epithelium-specific protein 65a, anticorps RPE65, anticorps Rpe65, anticorps ninaB, anticorps rpe65.S, anticorps rpe65.L, anticorps rpe65, anticorps rpe65c, anticorps rpe65b, anticorps rpe65a

Sujet:

Synonyms: Retinoid isomerohydrolase, All-trans-retinyl-palmitate hydrolase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase, RPE65

Background: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).

ID gène: 6121

UniProt: Q16518