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Recombinant SARS-CoV-2 Spike S1 anticorps

Reactivité: SARS Coronavirus-2 (SARS-CoV-2) ELISA, GICA Hôte: Human Chimeric H6 unconjugated Recombinant Antibody
N° du produit ABIN6953151
  • Antigène Voir toutes SARS-CoV-2 Spike S1 Anticorps
    SARS-CoV-2 Spike S1
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 44
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2)
    Hôte
    • 18
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Clonalité
    • 32
    • 9
    • 4
    Chimeric
    Conjugué
    • 39
    • 3
    • 1
    • 1
    • 1
    Cet anticorp SARS-CoV-2 Spike S1 est non-conjugé
    Application
    • 44
    • 9
    • 9
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Colloidal Gold Immunochromatography Assay (GICA)
    Attributs du produit
    Recombinant anti-SARS-CoV-2 spike is expressed from 293 cells (HEK293) ,It is a chimeric monoclonal antibody combining the mouse variable regions with the constant domains of human IgG1.
    Monoclonal mouse (varialbe region) / human (kappa / IgG1 constant)chimeric antibody.
    AA 16-685
    Purification
    Affinity-chromatography
    Immunogène
    Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa)
    Clone
    H6
    Isotype
    IgG1
    Featured
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  • Indications d'application
    ELISA 1:10000-1:50000
    GICA 1:500-1:25000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
  • Antigène
    SARS-CoV-2 Spike S1
    Abstract
    SARS-CoV-2 Spike S1 Produits
    Synonymes
    anticorps E2, anticorps Surface Glycoprotein, anticorps S
    Classe de substances
    Viral Protein
    Sujet
    Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.
    ID gène
    43740568
    UniProt
    P0DTC2
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