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SARS-CoV-2 Spike S1 anticorps (Biotin) Primary Antibody

Reactivité: SARS Coronavirus-2 (SARS-CoV-2) ELISA Hôte: Human Monoclonal H6
N° du produit ABIN6953155
$385.00
Plus shipping costs $45.00
100 μL
local_shipping Destination: Etats-Unis
Envoi sous 11 à 14 jours ouvrables
  • Antigène
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    SARS Coronavirus-2 (SARS-CoV-2)
    Hôte
    Human
    Clonalité
    Monoclonal
    Conjugué
    Cet anticorp SARS-CoV-2 Spike S1 est conjugé à/à la Biotin
    Application
    ELISA
    Attributs du produit
    Recombinant anti-SARS-CoV-2 spike Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
    Mouse scFv fusion with human IgG1 Fc
    AA 16-685
    Purification
    Affinity-chromatography
    Immunogène
    Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa)
    Clone
    H6
    Isotype
    IgG1
    Fragment
    scFv fragment
    Featured
    Discover our best selling SARS-CoV-2 Spike S1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
  • Antigène
    Sujet
    Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.
    ID gène
    43740568
    UniProt
    P0DTC2
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