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IQSEC1 anticorps (AA 451-550) (Alexa Fluor 647)

IQSEC1 Reactivité: Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 647
N° du produit ABIN6979885
  • Antigène Voir toutes IQSEC1 Anticorps
    IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
    Épitope
    • 14
    • 3
    • 2
    • 1
    AA 451-550
    Reactivité
    • 18
    • 6
    • 4
    Souris
    Hôte
    • 20
    Lapin
    Clonalité
    • 20
    Polyclonal
    Conjugué
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IQSEC1 est conjugé à/à la Alexa Fluor 647
    Application
    • 19
    • 12
    • 12
    • 7
    • 6
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GEP100
    Isotype
    IgG
    Top Product
    Discover our top product IQSEC1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
    Autre désignation
    GEP100/IQSEC1 (IQSEC1 Produits)
    Synonymes
    anticorps ARF-GEP100, anticorps ARFGEP100, anticorps BRAG2, anticorps GEP100, anticorps AW561907, anticorps BC026481, anticorps D6Ertd349e, anticorps cI-43, anticorps mKIAA0763, anticorps IQ motif and Sec7 domain 1, anticorps IQSEC1, anticorps Iqsec1
    Sujet

    Synonyms: ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, ARF GEP100, ARFGEP100, BRAG2, Brefeldin A resistant ARF GEF2, Brefeldin-resistant Arf-GEF 2 protein, GEP100, IQ motif and Sec7 domain 1, IQ motif and SEC7 domain-containing protein 1, IQEC1_HUMAN, Iqsec1, Kiaa0763.

    Background: The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin 1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.

    ID gène
    9922
    UniProt
    Q6DN90
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