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TAB3 anticorps (N-Term)

TAB3 Reactivité: Humain ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990489
  • Antigène Voir toutes TAB3 Anticorps
    TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))
    Épitope
    • 13
    • 8
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 40-90, N-Term
    Reactivité
    • 41
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 40
    • 1
    Lapin
    Clonalité
    • 40
    • 1
    Polyclonal
    Conjugué
    • 19
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TAB3 est non-conjugé
    Application
    • 26
    • 20
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.
    Purification
    TAB3 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3. The immunogen is located within amino acids 40 - 90 of TAB3.
    Isotype
    IgG
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    Discover our top product TAB3 Anticorps primaire
  • Indications d'application
    TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    TAB3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    TAB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))
    Autre désignation
    TAB3 (TAB3 Produits)
    Synonymes
    anticorps MAP3K7IP3, anticorps NAP1, anticorps 4921526G09Rik, anticorps Map3k7ip3, anticorps mKIAA4135, anticorps map3k7ip3, anticorps nap1, anticorps tab3, anticorps tab3-a, anticorps tab3-b, anticorps map3k7ip3l, anticorps si:ch211-232d19.8, anticorps si:dkey-30h22.6, anticorps TGF-beta activated kinase 1 and MAP3K7 binding protein 3, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 3, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 3 S homeolog, anticorps TAB3, anticorps Tab3, anticorps tab3.S, anticorps tab3
    Sujet
    TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
    ID gène
    257397
    NCBI Accession
    NP_690000
    UniProt
    Q8N5C8
    Pathways
    Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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