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BICD2 anticorps (AA 300-350)

BICD2 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990934
  • Antigène Voir toutes BICD2 Anticorps
    BICD2 (Bicaudal D Homolog 2 (BICD2))
    Épitope
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 300-350
    Reactivité
    • 24
    • 4
    • 4
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 22
    • 2
    Lapin
    Clonalité
    • 22
    • 2
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BICD2 est non-conjugé
    Application
    • 13
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Specificité
    This BICD2 antibody will not cross-react with BICD1.
    Purification
    BICD2 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    BICD2 antibody was raised against a 14 amino acid synthetic peptide from near the center of human BICD2. The immunogen is located within amino acids 300 - 350 of BICD2.
    Isotype
    IgG
    Top Product
    Discover our top product BICD2 Anticorps primaire
  • Indications d'application
    BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    BICD2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    BICD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    BICD2 (Bicaudal D Homolog 2 (BICD2))
    Autre désignation
    BICD2 (BICD2 Produits)
    Synonymes
    anticorps SMALED2, anticorps bA526D8.1, anticorps 0610027D24Rik, anticorps 1110005D12Rik, anticorps AA408834, anticorps mKIAA0699, anticorps MGC84972, anticorps BICD2, anticorps bicd2, anticorps BICD cargo adaptor 2, anticorps bicaudal D homolog 2 (Drosophila), anticorps BICD cargo adaptor 2 L homeolog, anticorps zgc:171572, anticorps BICD2, anticorps Bicd2, anticorps bicd2.L, anticorps bicd2, anticorps zgc:171572
    Sujet
    BICD2 Antibody: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
    Poids moléculaire
    Predicted: 94 kDa

    Observed: 100 kDa
    ID gène
    23299
    UniProt
    Q8TD16
    Pathways
    Maintenance of Protein Location
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