SKA3 anticorps (C-Term)

N° du produit ABIN6991192

Détail du produit anti-SKA3 anticorps

Antigène: SKA3 (Spindle and Kinetochore Associated Complex Subunit 3 (SKA3))

Épitope: AA 290-340, C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKA3 est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: SKA3 Antibody is affinity chromatography purified via peptide column.

Immunogène: SKA3 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human SKA3. The immunogen is located within amino acids 290 - 340 of SKA3.

Isotype: IgG

Information d'application

Indications d'application: SKA3 antibody can be used for detection of SKA3 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SKA3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SKA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SKA3

Antigène: SKA3 (Spindle and Kinetochore Associated Complex Subunit 3 (SKA3))

Autre désignation: SKA3 (SKA3 Produits)

Synonymes: anticorps C13orf3, anticorps RAMA1, anticorps RGD1307201, anticorps C12H13ORF3, anticorps fc23d11, anticorps si:rp71-68n21.13, anticorps wu:fc23d11, anticorps rama1, anticorps F630043A04Rik, anticorps spindle and kinetochore associated complex subunit 3, anticorps spindle and kinetochore associated complex subunit 3 L homeolog, anticorps SKA3, anticorps Ska3, anticorps ska3, anticorps ska3.L

Sujet: SKA3 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.

ID gène: 221150

NCBI Accession: NP_659498

UniProt: Q8IX90