FAM59A anticorps (C-Term)

N° du produit ABIN6991222

Détail du produit anti-FAM59A anticorps

Antigène: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Épitope: AA 630-680, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM59A est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: FAM59A Antibody is affinity chromatography purified via peptide column.

Immunogène: FAM59A antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAM59A. The immunogen is located within amino acids 630 - 680 of FAM59A.

Isotype: IgG

Information d'application

Indications d'application: FAM59A antibody can be used for detection of FAM59A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: FAM59A Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: FAM59A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FAM59A

Antigène: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Autre désignation: FAM59A (FAM59A Produits)

Synonymes: anticorps C18orf11, anticorps FAM59A, anticorps Gm944, anticorps C86169, anticorps Fam59a, anticorps mKIAA4238, anticorps fam59a, anticorps zgc:55634, anticorps GRB2 associated regulator of MAPK1 subtype 1, anticorps GRB2 associated, regulator of MAPK1, anticorps GAREM1, anticorps Garem1, anticorps garem

Sujet: FAM59A Antibody: FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.

ID gène: 64762

UniProt: Q9H706

Pathways: EGFR Signaling Pathway