ZMYM2 anticorps (N-Term)

N° du produit ABIN6991475

Détail du produit anti-ZMYM2 anticorps

Antigène: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Épitope: AA 120-170, N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZMYM2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: At least two isoforms of ZMYM2 are known to exist, this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.

Purification: ZMYM2 Antibody is affinity chromatography purified via peptide column.

Immunogène: ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2. The immunogen is located within amino acids 120 - 170 of ZMYM2.

Isotype: IgG

Information d'application

Indications d'application: ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZMYM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ZMYM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ZMYM2

Antigène: ZMYM2 (Zinc Finger, MYM-Type 2 (ZMYM2))

Autre désignation: ZMYM2 (ZMYM2 Produits)

Synonymes: anticorps ZMYM2, anticorps ZNF198, anticorps fc07a10, anticorps wu:fc07a10, anticorps si:dkey-51d17.6, anticorps fim, anticorps mym, anticorps ramp, anticorps scll, anticorps zfp198, anticorps znf198, anticorps MGC83724, anticorps FIM, anticorps MYM, anticorps RAMP, anticorps SCLL, anticorps 5830413P05Rik, anticorps Zfp198, anticorps Znf198, anticorps zinc finger MYM-type containing 2, anticorps zinc finger, MYM-type 2, anticorps zinc finger MYM-type containing 2 L homeolog, anticorps ZMYM2, anticorps zmym2, anticorps zmym2.L, anticorps Zmym2

Sujet: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1). The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3). As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4). Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5).

ID gène: 7750

UniProt: Q9UBW7