INPP4B anticorps (N-Term)

N° du produit ABIN6992164

Détail du produit anti-INPP4B anticorps

Antigène: INPP4B (Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa (INPP4B))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP4B est non-conjugé

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC)

Specificité: INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist, this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A.

Purification: INPP4B antibody is affinity chromatography purified via peptide column.

Immunogène: INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B. The immunogen is located within the last 50 amino acids of INPP4B.

Isotype: IgG

Information d'application

Indications d'application: INPP4B antibody can be used for detection of INPP4B by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: INPP4B antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: INPP4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur INPP4B

Antigène: INPP4B (Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa (INPP4B))

Autre désignation: INPP4B (INPP4B Produits)

Synonymes: anticorps E130107I17Rik, anticorps inositol polyphosphate-4-phosphatase, type II, anticorps inositol polyphosphate-4-phosphatase type II B, anticorps Inpp4b, anticorps INPP4B

Sujet: Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3).

Poids moléculaire: Predicted: 102 kDa

Observed: 100 kDa

ID gène: 8821

NCBI Accession: NP_003857

UniProt: Q9BS68