DAB2 anticorps
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- Antigène Voir toutes DAB2 Anticorps
- DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DAB2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human DAB2
- Isotype
- IgG
- Top Product
- Discover our top product DAB2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.6 mg/mL
- Buffer
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
- Autre désignation
- DAB2 (DAB2 Produits)
- Synonymes
- anticorps DOC-2, anticorps DOC2, anticorps 5730435J12Rik, anticorps AA960054, anticorps AI957090, anticorps D15Wsu122e, anticorps D630005B22Rik, anticorps Doc-2, anticorps Doc2, anticorps p96, anticorps DAB2, clathrin adaptor protein, anticorps disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila), anticorps Dab, mitogen-responsive phosphoprotein, homolog 2, anticorps disabled 2, mitogen-responsive phosphoprotein, anticorps DAB2, anticorps dab2, anticorps Dab2
- Sujet
- This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
- 82 kDa
- UniProt
- P98082
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
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