CXCR2 anticorps

N° du produit ABIN7002451

Détail du produit anti-CXCR2 anticorps

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCR2 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Synthetic peptide of human CXCR2

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CXCR2

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Autre désignation: IL8RB (CXCR2 Produits)

Synonymes: anticorps CD182, anticorps CDw128b, anticorps CMKAR2, anticorps IL8R2, anticorps IL8RA, anticorps IL8RB, anticorps CXC-R2, anticorps CXCR-2, anticorps CD128, anticorps CDw128, anticorps Cmkar2, anticorps Gpcr16, anticorps IL-8Rh, anticorps IL-8rb, anticorps Il8rb, anticorps mIL-8RH, anticorps C-X-C motif chemokine receptor 2, anticorps chemokine (C-X-C motif) receptor 2, anticorps Cxcr2, anticorps CXCR2

Sujet: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Poids moléculaire: 41 kDa

NCBI Accession: NP_001548

UniProt: P25025

Pathways: cAMP Metabolic Process