CACNA2D2 anticorps

N° du produit ABIN7244612

Détail du produit anti-CACNA2D2 anticorps

Antigène: CACNA2D2 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA2D2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human CACNA2D2

Isotype: IgG

Information d'application

Indications d'application: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.7 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CACNA2D2

Antigène: CACNA2D2 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2))

Autre désignation: CACNA2D2 (CACNA2D2 Produits)

Synonymes: anticorps CACNA2D, anticorps LUAC11.1, anticorps Cacna2d, anticorps a2d2, anticorps du, anticorps mKIAA0558, anticorps td, anticorps torpid, anticorps calcium voltage-gated channel auxiliary subunit alpha2delta 2, anticorps calcium channel, voltage-dependent, alpha 2/delta subunit 2, anticorps CACNA2D2, anticorps Cacna2d2

Sujet: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q9NY47

Pathways: Skeletal Muscle Fiber Development