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beta Catenin anticorps (pSer37)

Name: beta Catenin anticorps (pSer37)
Brand: antibodies-online
SKU: ABIN7250713
Price: 479 EUR
Availability: InStock

CATNB Reactivité: Humain, Souris, Rat WB, IF, ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated

Western Blot analysis of 293T cells using Phospho-Catenin beta (Ser37) Polyclonal Antibody at dilution of 1:2000

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using Phospho-Catenin beta (Ser37) Polyclonal Antibody at dilution of 1:200

IHC (p)

Immunofluorescence analysis of Human kidney tissue using Phospho-Catenin beta (Ser37) Polyclonal Antibody at dilution of 1:200

3 images

N° du produit ABIN7250713

Fiche de données

Antigène Voir toutes beta Catenin (CATNB) Anticorps

beta Catenin (CATNB) (Catenin, beta (CATNB))
Épitope
43

27

21

20

20

17

17

17

17

16

16

15

9

8

7

7

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer37
Reactivité
330

247

225

29

23

22

18

18

5

5

5

5

1

1

1

1

1

1

1

1
Humain, Souris, Rat
Hôte
270

59

4

2

1
Lapin
Anticorps secondaires appropriés
Clonalité
265

71
Polyclonal
Conjugué
122

22

16

15

15

15

15

15

11

10

9

9

9

9

9

8

4

4

4

4

4

4

1

1

1
Cet anticorp beta Catenin est non-conjugé
Application
206

158

120

118

73

62

61

48

35

31

22

8

7

4

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Attributs du produit

Phosphorylated antibody

Purification

Affinity purification

Immunogène

Synthesized peptide derived from human Catenin-beta around the phosphorylation site of Ser37

Isotype

IgG

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anti-Catenin, beta (CATNB) (AA 439-675) antibody
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anti-Catenin, beta (CATNB) (AA 439-675) antibody
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Indications d'application

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Store at -20°C. Avoid freeze / thaw cycles.
Antigène

beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation

Catenin beta (CATNB Produits)

Synonymes

anticorps Bfc, anticorps Catnb, anticorps Mesc, anticorps CTNNB, anticorps MRD19, anticorps armadillo, anticorps ctnnb, anticorps id:ibd2058, anticorps wu:fb73e10, anticorps wu:fi81c06, anticorps wu:fk25h01, anticorps beta-catenin, anticorps ctnnb1, anticorps CHBCAT, anticorps catenin (cadherin associated protein), beta 1, anticorps catenin beta 1, anticorps catenin (cadherin-associated protein), beta 1, anticorps catenin beta 1 L homeolog, anticorps Ctnnb1, anticorps CTNNB1, anticorps ctnnb1, anticorps ctnnb1.L

Sujet

Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Poids moléculaire

Observed_MW: 85 kDa
Calculated_MW: 85 kDa

UniProt

P35222

Pathways

Peptide Hormone Metabolism