TDG anticorps

N° du produit ABIN7256880

Détail du produit anti-TDG anticorps

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human TDG (NP_003202.3).

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: TDG (TDG Produits)

Synonymes: anticorps 5-MCDG, anticorps wu:fb44b11, anticorps zgc:110622, anticorps MGC82456, anticorps MGC89441, anticorps E130317C12Rik, anticorps JZA-3, anticorps Jza1, anticorps hTDG, anticorps thymine DNA glycosylase, anticorps thymine DNA glycosylase, tandem duplicate 1, anticorps putative g/t mismatch-specific thymine DNA glycosylase, anticorps G/T mismatch-specific thymine DNA glycosylase, anticorps thymine DNA glycosylase S homeolog, anticorps thymine-DNA glycosylase, anticorps TDG, anticorps tdg.1, anticorps Smp_149220, anticorps Tsp_05734, anticorps tdg.S, anticorps tdg, anticorps Tdg

Sujet: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.

ID gène: 6996

UniProt: Q13569

Pathways: Réparation de l'ADN, Chromatin Binding