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Ataxin 2 anticorps

ATXN2 Reactivité: Humain, Souris, Rat IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7259314
  • Antigène Voir toutes Ataxin 2 (ATXN2) Anticorps
    Ataxin 2 (ATXN2)
    Reactivité
    • 24
    • 23
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 36
    • 2
    • 1
    Lapin
    Clonalité
    • 38
    • 1
    Polyclonal
    Conjugué
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Ataxin 2 est non-conjugé
    Application
    • 34
    • 14
    • 13
    • 13
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    A synthetic peptide of human ATXN2
    Isotype
    IgG
  • Indications d'application
    IHC 1:50-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    Ataxin 2 (ATXN2)
    Autre désignation
    ATXN2 (ATXN2 Produits)
    Synonymes
    anticorps ASL13, anticorps ATX2, anticorps SCA2, anticorps TNRC13, anticorps 9630045M23Rik, anticorps AW544490, anticorps Sca2, anticorps ATXN2, anticorps MGC115230, anticorps ataxin 2, anticorps ataxin 2 L homeolog, anticorps ATXN2, anticorps Atxn2, anticorps atxn2.L
    Sujet
    This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.
    ID gène
    6311
    UniProt
    Q99700
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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