Complement Factor I anticorps

N° du produit ABIN7261564

Détail du produit anti-Complement Factor I anticorps

Antigène: Complement Factor I (CFI)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement Factor I est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human CFI (NP_000195.2).

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Complement Factor I

Antigène: Complement Factor I (CFI)

Autre désignation: CFI (CFI Produits)

Synonymes: anticorps cfi, anticorps MGC53615, anticorps Cfi, anticorps factor I, anticorps IF, anticorps gb:ai721528, anticorps ahus3, anticorps c3b-ina, anticorps c3bc4bi, anticorps c3bina, anticorps kaf, anticorps CFI, anticorps AHUS3, anticorps C3BINA, anticorps C3b-INA, anticorps FI, anticorps KAF, anticorps complement factor I S homeolog, anticorps complement factor I L homeolog, anticorps complement factor I, anticorps complement component factor i, anticorps cfi.S, anticorps cfi.L, anticorps CFI, anticorps cfi, anticorps Cfi

Sujet: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

ID gène: 3426

UniProt: P05156

Pathways: Système du Complément