Tuberin anticorps (AA 1601-1750)
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- Antigène Voir toutes Tuberin (TSC2) Anticorps
- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
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Épitope
- AA 1601-1750
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Tuberin est non-conjugé
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Application
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Tuberin
- Isotype
- IgG
- Top Product
- Discover our top product TSC2 Anticorps primaire
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- Indications d'application
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation." dans: International journal of biological macromolecules, Vol. 96, pp. 578-588, (2017) (PubMed).
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Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation." dans: International journal of biological macromolecules, Vol. 96, pp. 578-588, (2017) (PubMed).
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- Antigène
- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
- Autre désignation
- Tuberin (TSC2 Produits)
- Synonymes
- anticorps TSC2, anticorps fc16b02, anticorps tuberin, anticorps wu:fc16b02, anticorps LAM, anticorps TSC4, anticorps Nafld, anticorps Tcs2, anticorps Rc, anticorps TSC complex subunit 2, anticorps tuberin, anticorps hypothetical protein, anticorps tuberous sclerosis 2, anticorps TSC2, anticorps LOC5569538, anticorps tsc2, anticorps PGTG_00159, anticorps Tsc2
- Sujet
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Synonyms: LAM, TSC4, PPP1R160, Tuberin, Tuberous sclerosis 2 protein, TSC2
Background: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
- ID gène
- 7249
- UniProt
- P49815
- Pathways
- Signalisation RTK, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
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