FSHR anticorps (Extracellular)

N° du produit ABIN7043134

Cet anticorps Lapin Polyclonal détecte spécifiquement FSHR dans WB, IHC, IF, IC et LCI. Il présente une réactivité envers Rat.

Aperçu rapide pour FSHR anticorps (Extracellular) (ABIN7043134)

Antigène: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FSHR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-FSHR anticorps

Épitope: AA 128-140, Extracellular

Fonction: A Rabbit Polyclonal Antibody to FSH Receptor

Specificité: Extracellular, N-terminus

Réactivité croisée: Humain, Rat

Homologie: Mouse,human - 12,13 amino acid residues identical

Attributs du produit: Anti-FSHR (extracellular) Antibody is directed against an extracellular epitope of the rat FSH receptor. Anti-FSHR (extracellular) Antibody (ABIN7043134, ABIN7044277 and ABIN7044278) can be used in western blot and live cell imaging applications. It has been designed to recognize the FSH receptor from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)SNTGIKHLPAVHK, corresponding to amino acid residues 128-140 of rat FSHR

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7235325)

Blocking Peptide: (ABIN7235325)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur FSHR

Antigène: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Autre désignation: FSHR

Sujet: FSH receptor, Follicle-stimulating hormone receptor, Follitropin receptor, FSHRO,FSH (follicle stimulating hormone) is the central hormone of mammalian reproduction, necessary for gonadal development and maturation at puberty and for gamete production during the fertile phase of life1. Together with LH, this gonadotropin is produced and secreted by the pituitary gland as a highly heterogeneous glycoprotein2. The FSH receptor belongs to the family of G-protein coupled receptors, complex transmembrane proteins characterized by seven hydrophobic helices inserted in the plasma membrane and by intracellular and extracellular domains of variable dimensions depending on the type of ligand3. The intracellular portion of the FSH receptor is coupled to a Gs protein and, upon receptor activation by the hormonal interaction with the extracellular domain it initiates a cascade of events that ultimately leads to the specific biological effects of the gonadotropin.FSH acts by binding to specific receptors, localized exclusively in the gonads. The FSH receptor is expressed by two cell types of the gonad, namely Sertoli cells in the testis, and granulosa cells in the ovarian follicle4.Mutations of FSHR may cause primary or secondary amenorrhea, infertility, premature ovarian failure (POF) and ovarian hyperstimulation syndrome (OHSS)5. Mutations of FSHR may also play a role in the development of granulosa cell tumors of ovaries6.

Alternative names: FSHR, FSH receptor, Follicle-stimulating hormone receptor, Follitropin receptor, FSHRO

ID gène: 25449

NCBI Accession: NM_000145

UniProt: P20395

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling