KCNA3 anticorps (Extracellular)

N° du produit ABIN7043519

L’anticorps Cobaye Polyclonal anti-KCNA3 a été validé pour WB, IHC et IF. Il convient pour détecter KCNA3 dans des échantillons de Humain.

Aperçu rapide pour KCNA3 anticorps (Extracellular) (ABIN7043519)

Antigène: KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))

Reactivité: Humain

Hôte: Cobaye

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNA3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-KCNA3 anticorps

Épitope: AA 263-276, Extracellular

Fonction: A Guinea Pig Polyclonal Antibody to KV1.3 (KCNA3) Channel

Specificité: Extracellular loop between domains S1 and S2.

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse - 12,14 amino acid residues identical

Attributs du produit: Guinea pig Anti-KV1.3 (KCNA3) (extracellular) Antibody is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize KV1.3 potassium channel from mouse, rat, and human samples. The antigen used to immunize guinea pigs is the same as Anti-KV1.3 (KCNA3) (extracellular) Antibody (ABIN7043521, ABIN7044992 and ABIN7044993) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation, etc.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: KDYPASTSQDSFEA(C), corresponding to amino acid residues 263-276 of human KV1.3

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7236496)

Blocking Peptide: (ABIN7236496)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur KCNA3

Antigène: KCNA3 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))

Autre désignation: KCNA3

Sujet: Potassium voltage-gated channel subfamily A member 3,KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel, encoded by KCNA3, is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. The prominence of KV1.3 channels in these cells (particularly in T lymphocytes) directed much research attention. It was found that KV1.3 is the main channel responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2 Based on the central role of KV1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1

Alternative names: KV1.3, Potassium voltage-gated channel subfamily A member 3

ID gène: 3738

NCBI Accession: NM_002232

UniProt: P22001